C-Reactive Protein Modifies the Relationship Between Blood Pressure and Microalbuminuria
Key result
Higher CRP linked to ~4-fold greater microalbuminuria prevalence in patients with elevated MAP.
- P=0.0004
- n=8,592
Why the study?
The relationship between CRP and microalbuminuria is modest, and it is unclear whether CRP modifies the association between blood pressure and microalbuminuria.
Population
8592 inhabitants from Groningen, The Netherlands
Comparison
Different quartiles of CRP and mean arterial pressure levels
Design
Cross-sectional study
Authors
Discussion
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Member takes
Implication
CRP may flag higher microalbuminuria risk in hypertension; hypothesis-generating and requires longitudinal confirmation before practice change.
Study Design
Type
Cross-Sectional (n=8,592)
Structured PICO
P
Population
8,592 inhabitants from Groningen, The Netherlands, evaluated in a cross-sectional study to determine if C-reactive protein modifies the relationship between blood pressure and microalbuminuria.
O
Outcome
Prevalence and risk of microalbuminuriasurrogate
Main Result
p-value: p=0.0004
Elevated C-reactive protein levels significantly amplify the association between higher blood pressure and the presence of microalbuminuria.
Cite This Study
Stuveling et al. (2004) conducted a cross-sectional in Microalbuminuria (n=8,592). C-reactive protein (CRP) vs. Lower CRP quartiles was evaluated on Prevalence of microalbuminuria (p=0.0004). C-reactive protein modified the relationship between blood pressure and microalbuminuria, with prevalence rising from 6.7% to 25.1% across CRP quartiles in subjects with MAP >90 mm Hg (P<0.0001).