What question did this study set out to answer?

To characterize the maturation kinetics of IgG antibody avidity following SARS-CoV-2 infection and evaluate its relationship with disease severity.

September 11, 2020Clinical Infectious DiseasesOpen Access

Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Avidity Maturation and Association with Disease Severity

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Authors

RLRuben Yiqi LuoCornell University ICIndrani ChakrabortyDr. A.P.J. Abdul Kalam Technical University CYCassandra YunEisai (United States)

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Implication

Observational study reveals stronger IgG antibody avidity maturation in severe SARS-CoV-2 infections, indicating an association between immune binding strength and clinical severity.

Key Points

To characterize the maturation kinetics of IgG antibody avidity following SARS-CoV-2 infection and evaluate its relationship with disease severity.
Assessed IgG avidity kinetics across days since symptom onset using a novel label-free immunoassay technology.
Compared antibody avidity measurement trajectories between cohorts with mild versus severe COVID-19.
IgG avidity demonstrated a strong positive correlation with time elapsed since symptom onset.
Peak IgG avidity readings were significantly higher in patients with severe illness compared to those with mild disease.

Cite This Study

Luo et al. (2020) studied this question.

synapsesocial.com/papers/6aa94ced1ed6af7fb80e12c2 https://doi.org/10.1093/cid/ciaa1389

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Implication

Observational study reveals stronger IgG antibody avidity maturation in severe SARS-CoV-2 infections, indicating an association between immune binding strength and clinical severity.

Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Avidity Maturation and Association with Disease Severity

Discussion

Member takes

Implication

Key Points

Cite This Study

Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Avidity Maturation and Association with Disease Severity

Discussion

Member takes

Implication

Key Points

Cite This Study

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