Key result
Quinidine therapy linked to reversible bluish discoloration of the hands, feet, and lips.
Case Report (n=1)
Quinidine therapy in pediatric epilepsy may be associated with bluish skin discoloration that improves upon discontinuation.
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Quinidine may cause slowly reversible bluish discoloration in KCNT1 epilepsy; leaves open need for monitoring in future precision trials.
Baumer et al. (2017) conducted a case report in Migrating partial seizures of infancy due to a de novo KCNT1 mutation (n=1). Quinidine was evaluated on Bluish discoloration of the hands, feet, and lips. Quinidine therapy (40 mg/kg/d) in a 9-month-old boy with KCNT1-associated epilepsy resulted in bluish discoloration of the hands, feet, and lips that improved after discontinuation.
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