Key result
Rotavirus gastroenteritis linked to a fully reversible lesion in the splenium of the corpus callosum.
Why the study?
Transient lesions in the splenium of the corpus callosum can result from various causes including infection, but cases related to rotavirus infection are not well characterized.
Case Report (n=1)
No
Rotavirus infection can cause a transient, reversible lesion in the splenium of the corpus callosum presenting with seizures.
Alerts clinicians to consider rotavirus in reversible splenial lesions with seizures; extends known etiologies but remains hypothesis-generating.
Transient signal changes in magnetic resonance imaging (MRI) of the splenium of the corpus callosum (SCC) can result from many different reasons, including encephalitis and encephalopathy caused by infection, seizures, metabolic disorders and asphyxia. We report a case of a 6-year-old Polish girl with rotavirus infection demonstrating a reversible SCC lesion on diffusion-weighted MRI images. She presented six episodes of generalized tonic seizures with mild acute gastroenteritis. Stool test for rotavirus antigen was positive. At the time of admission imaging showed the hyperintense region in T2-weighted and fluid-attenuated inversion-recovery MRI, a well-defined lesion in the splenium of the corpus callosum with restricted diffusion in diffusion-weighted MRI and no enhancement in post contrast T1-weighted imaging. Her first EEG showed slow brain activity in the posterior occipitotemporal portion, consisting mainly of theta waves with a frequency of 4.5-5.5 Hz and amplitude of 40 uV. The lesion had completely disappeared on follow-up MRI 10 days later. The patient recovered fully without any sequelae.
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Mazur‐Melewska et al. (2015) conducted a case report in Rotavirus infection with transient lesion in the splenium of the corpus callosum (MERS) (n=1). Rotavirus infection was evaluated on Clinical and radiological recovery. A 6-year-old girl with rotavirus gastroenteritis developed a transient lesion in the splenium of the corpus callosum that completely resolved on follow-up MRI without any neurological sequelae.
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