Key result
Indicator-dilution methods require a ventricular mixing chamber to accurately determine true pulmonary blood volume.
Why the study?
The validity of pulmonary blood volume determination methods with or without a ventricular mixing chamber was uncertain.
Does the presence of a ventricular mixing chamber improve the validity of true pulmonary blood volume determination by indicator-dilution methods?
Population
96 subjects
Comparison
Indicator-dilution methods with ventricular mixing chamber vs without ventricular mixing chamber
Design
Other study design
Authors
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Indicator-dilution pulmonary blood volume estimates may be invalid without ventricular mixing; leaves open in vivo validation.
Does the presence of a ventricular mixing chamber improve the validity of true pulmonary blood volume determination by indicator-dilution methods?
A ventricular mixing chamber is essential for valid determination of true pulmonary blood volume using indicator-dilution methods.
Samet et al. (1966) studied this question. Indicator-dilution methods require a right or left ventricular mixing chamber between injection and sampling sites for the valid determination of true pulmonary blood volume.
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