Key result
Oral contraceptives exacerbate severe hypertension unmasking familial focal segmental glomerulosclerosis in a young woman.
Why the study?
Young-adult hypertension can be a presenting feature of familial renal disease such as focal segmental glomerulosclerosis, complicating diagnosis and management.
Population
1 previously healthy 20-year-old obese white woman with severe hypertension and family history of FSGS
Comparison
Discontinuation of oral contraceptive pills and initiation of antihypertensive therapy with weight reduction counseling
Design
Case report
Follow-up
6 months
Authors
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Severe hypertension after OCP initiation may signal familial FSGS; hypothesis-generating and leaves open whether targeted screening improves outcomes.
Case Report (n=1)
Severe hypertension in a young adult following oral contraceptive initiation may unmask underlying familial renal disease such as focal segmental glomerulosclerosis.
Joel Handler (2004) conducted a case report in Hypertension and familial renal disease (focal segmental glomerulosclerosis) (n=1). Oral contraceptive pills was evaluated. A 20-year-old woman presented with severe hypertension exacerbated by oral contraceptive pills, leading to a diagnosis of familial focal segmental glomerulosclerosis.