What is the clinical evidence from this study?

Study design: Observational. Population: First myocardial infarction (n=26). Intervention: Magnetic resonance tissue tagging and strain analysis vs. Two-dimensional wall thickening (WT) analysis. Primary outcome: Sensitivity for detecting dysfunctional myocardium of electrocardiographically and angiographically defined infarct areas (p=<0.005).

What question did this study set out to answer?

To compare the diagnostic utility of regional myocardial strain analysis against conventional wall thickening analysis for distinguishing infarcted tissue from remote non-infarcted myocardium.

September 15, 2026Journal of the American College of CardiologyOpen Access

Quantification of regional contractile function after infarction: strain analysis superior to wall thickening analysis in discriminating infarct from remote myocardium

Q: What are the key findings of this study?

Magnetic resonance strain analysis was more accurate than wall thickening analysis in discriminating dysfunctional from functional myocardium, with 92% sensitivity and 99% specificity.

Q: What question did this study set out to answer?

To compare the diagnostic utility of regional myocardial strain analysis against conventional wall thickening analysis for distinguishing infarcted tissue from remote non-infarcted myocardium.

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Key result

MR strain analysis outperforms WT analysis in detecting dysfunctional myocardium with ~92% sensitivity.

P<0.005
n=26

Why the study?

Does MR strain analysis improve the detection of dysfunctional myocardium compared to wall thickening analysis in patients with myocardial infarction?

Population

26 subjects (13 control subjects and 13 patients with a first myocardial infarction)

Comparison

Quantitative assessment of contractile function… vs Two-dimensional planar wall thickening analysis

Design

Cross-sectional

Authors

MGMarco Götte ARAlbert C. van Rossum JTJos W. R. Twisk

Discussion

Member takes

Overview

MR tissue tagging with strain analysis is more accurate than planar wall thickening analysis for discriminating dysfunctional from functional myocardium after myocardial infarction.

Key Points

To compare the diagnostic utility of regional myocardial strain analysis against conventional wall thickening analysis for distinguishing infarcted tissue from remote non-infarcted myocardium.
Quantified regional contractile function in myocardial segments following myocardial infarction.
Compared deformation-based strain measurements directly with radial wall thickening metrics across infarcted and remote myocardial territories.
Myocardial strain analysis demonstrated superior accuracy over wall thickening analysis in discriminating infarcted myocardium from remote healthy segments.
Quantitative deformation parameters detected regional contractile impairment with higher sensitivity than regional wall thickening measurements.

Study Design

Type

Observational (n=26)

Structured PICO

Does MR strain analysis improve the detection of dysfunctional myocardium compared to wall thickening analysis in patients with myocardial infarction?

Population

26 participants, comprising 13 control subjects and 13 patients with a first myocardial infarction, evaluated for regional contractile function.

Exposure

Quantitative assessment of contractile function by magnetic resonance (MR) tissue tagging and strain analysis

Comparator

Two-dimensional planar wall thickening (WT) analysis

Outcome

Discrimination of dysfunctional from functional myocardium (sensitivity and specificity for detecting dysfunctional myocardium of electrocardiographically and angiographically defined infarct areas)surrogate

Main Result

Absolute Event Rate: 92% vs 69%

p-value: p=<0.005

MR tissue tagging with strain analysis is more accurate than planar wall thickening analysis for discriminating dysfunctional from functional myocardium after myocardial infarction.

Cite This Study

Götte et al. (2001) conducted an observational in First myocardial infarction (n=26). Magnetic resonance tissue tagging and strain analysis vs. Two-dimensional wall thickening (WT) analysis was evaluated on Sensitivity for detecting dysfunctional myocardium of electrocardiographically and angiographically defined infarct areas (p=<0.005). Magnetic resonance strain analysis was more accurate than wall thickening analysis in discriminating dysfunctional from functional myocardium, with 92% sensitivity and 99% specificity.

synapsesocial.com/papers/6aa9b59183705aff8b6d8ec2 https://doi.org/10.1016/s0735-1097(00)01186-4

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September 15, 2026Journal of the American College of CardiologyOpen Access

Quantification of regional contractile function after infarction: strain analysis superior to wall thickening analysis in discriminating infarct from remote myocardium

View Full Paper

Ask AI

Bookmark

Key result

MR strain analysis outperforms WT analysis in detecting dysfunctional myocardium with ~92% sensitivity.

P<0.005
n=26

Why the study?

Does MR strain analysis improve the detection of dysfunctional myocardium compared to wall thickening analysis in patients with myocardial infarction?

Population

26 subjects (13 control subjects and 13 patients with a first myocardial infarction)

Comparison

Quantitative assessment of contractile function… vs Two-dimensional planar wall thickening analysis

Design

Cross-sectional

Authors

MGMarco Götte ARAlbert C. van Rossum JTJos W. R. Twisk

Discussion

Member takes

Overview

MR tissue tagging with strain analysis is more accurate than planar wall thickening analysis for discriminating dysfunctional from functional myocardium after myocardial infarction.

Key Points

To compare the diagnostic utility of regional myocardial strain analysis against conventional wall thickening analysis for distinguishing infarcted tissue from remote non-infarcted myocardium.
Quantified regional contractile function in myocardial segments following myocardial infarction.
Compared deformation-based strain measurements directly with radial wall thickening metrics across infarcted and remote myocardial territories.
Myocardial strain analysis demonstrated superior accuracy over wall thickening analysis in discriminating infarcted myocardium from remote healthy segments.
Quantitative deformation parameters detected regional contractile impairment with higher sensitivity than regional wall thickening measurements.

Study Design

Type

Observational (n=26)

Structured PICO

Does MR strain analysis improve the detection of dysfunctional myocardium compared to wall thickening analysis in patients with myocardial infarction?

Population

26 participants, comprising 13 control subjects and 13 patients with a first myocardial infarction, evaluated for regional contractile function.

Exposure

Quantitative assessment of contractile function by magnetic resonance (MR) tissue tagging and strain analysis

Comparator

Two-dimensional planar wall thickening (WT) analysis

Outcome

Main Result

Absolute Event Rate: 92% vs 69%

p-value: p=<0.005

MR tissue tagging with strain analysis is more accurate than planar wall thickening analysis for discriminating dysfunctional from functional myocardium after myocardial infarction.

Cite This Study

synapsesocial.com/papers/6aa9b59183705aff8b6d8ec2 https://doi.org/10.1016/s0735-1097(00)01186-4

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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