February 18, 1997Circulation
Detection and Quantification of Dysfunctional Myocardium by Magnetic Resonance Imaging
Why the study?
Does three-dimensional quantitative analysis of cine MR images accurately quantify the extent of regional left ventricular dysfunction in patients after anterior myocardial infarction?
Population
25 patients after anterior myocardial infarction and a database of 48 healthy volunteers
Comparison
Short-axis cardiac cine magnetic resonance… vs Enzymatically determined infarct size and…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports cine MR quantification of post-MI LV dysfunction; hypothesis-generating pending prospective validation.
Structured PICO
Does three-dimensional quantitative analysis of cine MR images accurately quantify the extent of regional left ventricular dysfunction in patients after anterior myocardial infarction?
P
Population
25 patients after anterior myocardial infarction (at 21 +/- 2.1 days after acute onset) and a database of 48 healthy volunteers
I
Intervention
Short-axis cardiac cine magnetic resonance (MR) imaging analyzed with MASS version 1.0 software (modified centerline method and three-dimensional analysis approach)
C
Comparator
Enzymatically determined infarct size and healthy volunteer database
O
Outcome
Correlation between quantity of dysfunctional myocardium by MR imaging and enzymatically calculated infarct sizesurrogate
Three-dimensional quantitative analysis of cine MR images accurately quantifies regional left ventricular dysfunction in infarcted hearts, correlating strongly with enzymatic infarct size.
Cite This Study
Holman et al. (1997) studied this question.