What does this research mean for the field?

Rapid cine magnetic resonance (MR) imaging accurately quantifies regional myocardial function and identifies abnormal wall motion in patients with ischemic heart disease, correlating well with established methods like echocardiography and contrast ventriculography. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study aims to evaluate the effectiveness of rapid cine MR imaging in quantifying left ventricular function and regional wall motion abnormalities.

March 1, 1988American Journal of Roentgenology

Quantification of regional myocardial function by rapid cine MR imaging

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Why the study?

Does rapid cine MR imaging improve the quantification of regional myocardial function in normal subjects and patients with ischemic heart disease?

Population

28 subjects total: 13 normal subjects and 15 patients with ischemic heart disease and regional wall-motion…

Comparison

Rapid MR imaging acquiring 15 to 20 images per… vs Echocardiography and/or contrast ventriculography.

Design

Cross-sectional

Authors

PPP W Pflugfelder USU Sechtem RWRichard D. White

Discussion

Member takes

Overview

Cine MR may aid regional wall motion assessment in ischemic disease; supports feasibility but leaves open prospective validation before clinical adoption.

Key Points

The study aims to evaluate the effectiveness of rapid cine MR imaging in quantifying left ventricular function and regional wall motion abnormalities.
Acquired 15 to 20 MR images per cardiac cycle using partial flip angles and gradient-refocused echoes.
Assessed regional wall motion qualitatively through cine display and quantitatively by measuring myocardial thickness in six left ventricular segments.
Included 13 normal subjects and 15 patients with ischemic heart disease.
In normal subjects, systolic wall thickening was observed to be 48% +/- 28%.
In ischemic heart disease patients, wall motion abnormalities were noted in 40 of 90 segments, correlating well with echocardiography.
Systolic wall thickening percentages were significantly lower in abnormal segments, ranging from 6% +/- 18% to -13% +/- 25%.

Structured PICO

Does rapid cine MR imaging improve the quantification of regional myocardial function in normal subjects and patients with ischemic heart disease?

Population

28 subjects total: 13 normal subjects and 15 patients with ischemic heart disease and regional wall-motion abnormalities proved by echocardiography and/or contrast ventriculography.

Intervention

Rapid (cine) MR imaging acquiring 15 to 20 images per cardiac cycle using partial flip angles, short repetition times, and gradient-refocused echoes.

Comparator

Echocardiography and/or contrast ventriculography (used as reference standard).

Outcome

Qualitative and quantitative assessment of regional wall motion (myocardial thickness at end-diastole and end-systole in six left ventricular segments).surrogate

Rapid cine MR imaging is a potentially useful technique for both qualitative assessment and quantification of regional myocardial function.

Cite This Study

Pflugfelder et al. (1988) studied this question.

synapsesocial.com/papers/6a15625679ff98d0de4e8cd5 https://doi.org/10.2214/ajr.150.3.523

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March 1, 1988American Journal of Roentgenology

Quantification of regional myocardial function by rapid cine MR imaging

View Full Paper

Ask AI

Bookmark

Why the study?

Does rapid cine MR imaging improve the quantification of regional myocardial function in normal subjects and patients with ischemic heart disease?

Population

28 subjects total: 13 normal subjects and 15 patients with ischemic heart disease and regional wall-motion…

Comparison

Rapid MR imaging acquiring 15 to 20 images per… vs Echocardiography and/or contrast ventriculography.

Design

Cross-sectional

Authors

PPP W Pflugfelder USU Sechtem RWRichard D. White

Discussion

Member takes

Overview

Cine MR may aid regional wall motion assessment in ischemic disease; supports feasibility but leaves open prospective validation before clinical adoption.

Key Points

The study aims to evaluate the effectiveness of rapid cine MR imaging in quantifying left ventricular function and regional wall motion abnormalities.
Acquired 15 to 20 MR images per cardiac cycle using partial flip angles and gradient-refocused echoes.
Assessed regional wall motion qualitatively through cine display and quantitatively by measuring myocardial thickness in six left ventricular segments.
Included 13 normal subjects and 15 patients with ischemic heart disease.
In normal subjects, systolic wall thickening was observed to be 48% +/- 28%.
In ischemic heart disease patients, wall motion abnormalities were noted in 40 of 90 segments, correlating well with echocardiography.
Systolic wall thickening percentages were significantly lower in abnormal segments, ranging from 6% +/- 18% to -13% +/- 25%.

Structured PICO

Does rapid cine MR imaging improve the quantification of regional myocardial function in normal subjects and patients with ischemic heart disease?

Population

28 subjects total: 13 normal subjects and 15 patients with ischemic heart disease and regional wall-motion abnormalities proved by echocardiography and/or contrast ventriculography.

Intervention

Rapid (cine) MR imaging acquiring 15 to 20 images per cardiac cycle using partial flip angles, short repetition times, and gradient-refocused echoes.

Comparator

Echocardiography and/or contrast ventriculography (used as reference standard).

Outcome

Qualitative and quantitative assessment of regional wall motion (myocardial thickness at end-diastole and end-systole in six left ventricular segments).surrogate

Rapid cine MR imaging is a potentially useful technique for both qualitative assessment and quantification of regional myocardial function.

Cite This Study

Pflugfelder et al. (1988) studied this question.

synapsesocial.com/papers/6a15625679ff98d0de4e8cd5 https://doi.org/10.2214/ajr.150.3.523

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

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