Key result
Arterial hypertension in familial hypercholesterolemia is linked to ~481% higher ASCVD odds.
Why the study?
Arterial hypertension and familial hypercholesterolemia are major ASCVD risk factors, but the role of hypertension on lipid profile and ASCVD prevalence in FH patients was unclear.
Does arterial hypertension increase the prevalence of ASCVD and alter the lipid profile in patients with familial hypercholesterolemia?
Cohort (n=4,083)
Yes
Does arterial hypertension increase the prevalence of ASCVD and alter the lipid profile in patients with familial hypercholesterolemia?
Answers are grounded in this paper and cite their sources.
Arterial hypertension in patients with familial hypercholesterolemia is associated with a nearly 6-fold increased odds of ASCVD, as well as lower HDL-C and higher triglyceride levels.
Background: Arterial hypertension (HTN) and familial hypercholesterolemia (FH) represent major atherosclerotic cardiovascular disease (ASCVD) risk factors. Objective: To investigate whether HTN plays a role in the lipid profile and prevalence of ASCVD in patients with FH. Methods: This is a pooled analysis of three FH cohorts (HELLAS, CZECH, and CHINA) reporting the lipid profile, namely low-density lipoprotein cholesterol (LDL-C), total cholesterol (TCHOL), triglycerides (TRGs), and high-density lipoprotein cholesterol (HDL-C), as well as history of ASCVD among FH patients with or without HTN. Results: A total of 4083 FH patients (1943 males), with a mean age of 47.2 years old were included in the analysis. The pooled analysis revealed that 1140 HTN (+) FH patients had 5.81 times the odds of ASCVD compared with the 2943 HTN (–) FH patients (odds ratio: 5.81, 95% confidence interval [CI]: 4.93, 6.84, P < 0.00001). Regarding HDL-C levels, they were significantly lower in HTN (+) patients when compared with HTN (–) FH patients (mean difference [MD]: –4.10, 95% CI: –5.16, –3.03, P < 0.00001), while TRGs were higher in HTN (+) patients when compared with HTN (–) FH patients (MD: 27.72, 95% CI: 21.76, 33.69, P < 0.00001). No significant difference in LDL-C (MD: –12.23, 95% CI: –33.65, 9.20, P = 0.26) and TCHOL (MD: –8.83 mg/dL, 95% CI: –32.30, 14.64, P = 0.46) levels between HTN (+) and HTN (–) FH patients was observed. Conclusions: FH patients with HTN have a higher prevalence of ASCVD, while they exert lower HDL-C and higher TRG levels compared with FH patients without HTN.
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Agouridis et al. (2026) conducted a cohort in Familial Hypercholesterolemia (n=4,083). Arterial hypertension vs. No arterial hypertension was evaluated on Atherosclerotic cardiovascular disease (ASCVD) (OR 5.81, 95% CI 4.93-6.84, p=<0.00001). Arterial hypertension in patients with familial hypercholesterolemia was associated with significantly higher odds of atherosclerotic cardiovascular disease (OR 5.81; 95% CI 4.93-6.84; P<0.00001).
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