Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 2026Journal of Cellular and Molecular MedicineOpen Access

SFRP2 Potentiates Metastasis of Colon Cancer by Enhancing Snai1 Protein Stability via USP11

View Full Paper
Ask AI
Bookmark
Share

Authors

YKYanshen KuangXLXin LiuMKMu Ke

Discussion

Loading...

Member takes

Overview

Preclinical study reveals that SFRP2 accelerates cell invasion and metastasis in colon cancer models, highlighting a potential therapeutic target.

Key Points

  • To elucidate the molecular mechanisms by which secreted frizzled-related protein 2 (SFRP2) promotes colon cancer progression and metastatic spread.
  • Conducted in vitro migration, invasion, and proliferation assays in colon cancer cell lines.
  • Investigated protein-protein interactions, deubiquitination by USP11, and downstream PI3K/AKT/mTOR pathway activation.
  • Evaluated metastatic potential and tumor dissemination using in vivo animal models.
  • SFRP2 significantly enhanced colon cancer cell migration and invasion without altering cellular proliferation rates.
  • SFRP2 stabilized Snai1 by suppressing its ubiquitination through the deubiquitinase USP11, establishing a positive feedback loop that amplified both proteins.
  • The SFRP2-Snai1 axis stimulated the PI3K/AKT/mTOR signaling cascade and markedly increased metastatic burden in vivo.

Cite This Study

Kuang et al. (2026) studied this question.

synapsesocial.com/papers/6aa9df69bf5b892176fc9058https://doi.org/10.1111/jcmm.71318
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1SFRP2 drives aerobic glycolysis and tumor progression in ovarian cancer by transcriptional upregulation of PTK2B2026
  2. 2Identification of epigenetic silencing of the SFRP2 gene in colorectal cancer as a clinical biomarker and molecular significance2024 · 9 citations
  3. 3Secreted frizzled-related protein 4 (sFRP4) in cancer – Dual roles in tumorigenesis and therapeutic potential: A review2025 · 2 citations
  4. 4A74-34 Functional Analysis of Secreted Frizzled-related Protein 2 in Pulmonary Fibrosis2026
  5. 5Targeting sFRP1 with WAY-316606 Suppresses Proliferation, Migration, and Invasion in Metastatic Melanoma2026