Key result
Plaque-type psoriasis is linked to ~17% higher PWV and increased CIMT versus healthy controls.
Why the study?
Systemic inflammation in psoriasis patients may contribute to premature atherosclerosis, but the relationship with subclinical atherosclerosis in patients without traditional risk factors is unclear.
Does plaque-type psoriasis increase subclinical atherosclerosis (measured by PWV and CIMT) in patients without traditional cardiovascular risk factors compared to healthy individuals?
Comparison
Plaque-type psoriasis patients vs healthy individuals
Design
Case-control study
Authors
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Psoriasis may associate with subclinical atherosclerosis on PWV/CIMT; leaves open causal role of inflammation and need for prospective validation.
Case-Control (n=117)
Does plaque-type psoriasis increase subclinical atherosclerosis (measured by PWV and CIMT) in patients without traditional cardiovascular risk factors compared to healthy individuals?
Absolute Event Rate: 7.04% vs 6.03%
p-value: p=<0.001
Plaque-type psoriasis is associated with increased subclinical atherosclerosis, as measured by PWV and CIMT, even in the absence of traditional cardiovascular risk factors.
Emre Altekin (2012) conducted a case-control in Plaque type psoriasis (n=117). Plaque type psoriasis vs. Healthy individuals was evaluated on Pulse wave velocity (PWV) (p=<0.001). Plaque-type psoriasis was associated with higher pulse wave velocity (7.04 vs. 6.03 m/sn, p<0.001) and carotid intima media thickness compared to healthy controls.
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