Key result
Moderate to severe plaque psoriasis is linked to ~17% higher carotid-femoral pulse wave velocity versus controls.
Why the study?
Patients with moderate to severe chronic plaque psoriasis have a higher prevalence of cardiovascular risk factors and atherosclerosis, but the association with arterial stiffness is unclear.
Is moderate to severe chronic plaque psoriasis associated with increased arterial stiffness compared to other skin diseases?
Population
39 adult patients with moderate to severe chronic plaque psoriasis and 38 controls with other skin diseases
Comparison
Chronic plaque psoriasis vs skin diseases other than psoriasis
Design
Cross-sectional study
Authors
Loading...
Supports heightened CV vigilance in severe psoriasis; leaves open causality and need for longitudinal confirmation.
Cross-Sectional (n=77)
Is moderate to severe chronic plaque psoriasis associated with increased arterial stiffness compared to other skin diseases?
Absolute Event Rate: 8.88% vs 7.57%
p-value: p=0.001
Moderate to severe chronic plaque psoriasis is independently associated with increased arterial stiffness, highlighting a potential link between psoriasis duration and atherosclerosis risk.
Gisondi et al. (2008) conducted a cross-sectional in Moderate to severe chronic plaque psoriasis (n=77). Moderate to severe chronic plaque psoriasis vs. Patients with skin diseases other than psoriasis was evaluated on Carotid-femoral pulse wave velocity (PWVcf) (p=0.001). Moderate to severe chronic plaque psoriasis was associated with significantly higher carotid-femoral pulse wave velocity compared to controls (8.88 vs. 7.57 m/s; p=0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: