Key result
Psoriasis is linked to ~10% higher arterial stiffness compared with healthy controls.
Why the study?
Psoriasis is associated with premature atherosclerosis, but the underlying mechanism linking disease activity, systemic inflammation, and vascular function remains unclear.
Does psoriasis increase arterial stiffness and microvascular dysfunction compared to healthy controls?
Comparison
Patients with psoriasis vs age- and sex-matched healthy controls
Design
Case-control study
Authors
Loading...
Young patients with psoriasis exhibit increased arterial stiffness that is independently associated with systemic inflammation (hs-CRP), suggesting a mechanism for premature atherosclerosis.
Case-Control (n=102)
Does psoriasis increase arterial stiffness and microvascular dysfunction compared to healthy controls?
Absolute Event Rate: 14.5% vs 13.2%
p-value: p=<0.01
Young patients with psoriasis exhibit increased arterial stiffness that is independently associated with systemic inflammation (hs-CRP), suggesting a mechanism for premature atherosclerosis.
Yiu et al. (2010) conducted a case-control in Psoriasis (n=102). Psoriasis vs. Age- and sex-matched controls was evaluated on Brachial to ankle pulse wave velocity (baPWV) (p=<0.01). Patients with psoriasis had significantly higher arterial stiffness than controls (baPWV 14.5 vs 13.2 m/s; P<0.01), and each 1 mg/L increase in hs-CRP predicted a 0.12 m/s increase in baPWV.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: