What does this research mean for the field?

Variation in DNA methylation within and upstream of the TNF-beta gene correlates inversely with cell-type expression, being lowest in T lymphocytes and highest in neutrophils, indicating an important regulatory role. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1990The Journal of Immunology

Genetic variability at the human tumor necrosis factor loci.

Q: What is the clinical evidence from this study?

Study design: Other. Intervention: Genetic variability and DNA methylation at TNF loci. Primary outcome: Allelic restriction fragment length polymorphism (RFLP) and DNA methylation of the TNF-beta gene.

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Key result

DNA methylation variation at AccI sites may regulate TNF-beta expression, being lowest in T lymphocytes.

Authors

GWGraham C. WebbAustralian National University DCDavid ChaplinNorthwest Nazarene University

Discussion

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Implication

Hypothesis-generating for TNF-beta epigenetic control; leaves open clinical translation pending validation in disease cohorts.

PICO

Exposure / Comparator

Genetic variability and DNA methylation at TNF loci

Primary Outcome

Allelic restriction fragment length polymorphism (RFLP) and DNA methylation of the TNF-beta gene

Cite This Study

Webb et al. (1990) studied this question. Genetic variability and DNA methylation at TNF loci was evaluated on Allelic restriction fragment length polymorphism (RFLP) and DNA methylation of the TNF-beta gene. Variation in DNA methylation at AccI sites within and upstream of the TNF-beta gene may play an important role in regulating its expression, with methylation being lowest in T lymphocytes.

synapsesocial.com/papers/6aa9ece928eb848784fc9202 https://doi.org/10.4049/jimmunol.145.4.1278

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Genetic variability at the human tumor necrosis factor loci.

Discussion

Member takes

Implication

PICO

Cite This Study

Genetic variability at the human tumor necrosis factor loci.

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider