Inherited Variability of Tumor Necrosis Factor Production and Susceptibility to Infectious Disease
Key result
TNF promoter -308 polymorphism associates with susceptibility to severe malaria, leishmaniasis, scarring trachoma, and lepromatous leprosy.
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
TNF-308 variant may inform susceptibility assessment in endemic regions; leaves open functional mechanisms and clinical utility.
PICO
P
Population
Infectious diseases (severe malaria, leishmaniasis, scarring trachoma, lepromatous leprosy)
E
Exposure / Comparator
Tumor necrosis factor (TNF) promoter polymorphism at nucleotide -308
O
Primary Outcome
Susceptibility to infectious disease
Genetic variability in TNF production, particularly a polymorphism at nucleotide -308, is associated with susceptibility to various severe infectious diseases.
Limitations
- Experimental data indicating this polymorphism acts to upregulate TNF transcription remains controversial
- Detailed analysis of multiple genetic markers and more sophisticated investigations are required to understand the molecular basis of these disease associations
Cite This Study
Knight et al. (1999) conducted a review in Infectious diseases (severe malaria, leishmaniasis, scarring trachoma, lepromatous leprosy). Tumor necrosis factor (TNF) promoter polymorphism at nucleotide -308 was evaluated on Susceptibility to infectious disease. A single nucleotide polymorphism at nucleotide -308 in the TNF promoter has been associated with susceptibility to severe malaria, leishmaniasis, scarring trachoma, and lepromatous leprosy.