Key result
Adrenaline induces weaker platelet aggregation in hirudin versus citrated plasma due to calcium deprivation.
Why the study?
The anticoagulant used for blood collection may modify platelet aggregation, affecting adrenaline-induced platelet reactions.
Does the type of anticoagulant (hirudin vs citrate) modify adrenaline-induced aggregation of human platelets?
Population
Human platelets in platelet-rich plasma
Comparison
Adrenaline in platelet-rich hirudin plasma vs adrenaline in platelet-rich citrated plasma
Design
Preclinical study
Authors
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Anticoagulant choice alters adrenaline-induced platelet aggregation in vitro; leaves open optimal conditions for modeling human responses in vivo.
Does the type of anticoagulant (hirudin vs citrate) modify adrenaline-induced aggregation of human platelets?
Adrenaline-induced platelet aggregation is modified by the anticoagulant used, with citrate causing biphasic aggregation due to calcium deprivation compared to hirudin.
Glusa et al. (2009) studied this question. Adrenaline in hirudin plasma vs. Adrenaline in citrated plasma was evaluated on Platelet aggregation and 14C-serotonin release. Adrenaline induced weak primary aggregation in hirudin plasma compared to biphasic aggregation with 14C-serotonin release in citrated plasma, likely due to calcium ion deprivation by citrate.
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