Key result
Recombinant hirudin is a suitable anticoagulant for studying platelet functions, causing significantly lower spontaneous platelet aggregation compared to heparin or citrate without altering reactions.
Why the study?
Does recombinant hirudin alter platelet functions compared to heparin or citrate in anticoagulated blood?
Population
Blood samples
Comparison
Recombinant hirudin as an anticoagulant vs Heparin or citrate
Design
Preclinical
Authors
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Recombinant hirudin may suit animal platelet assays better than heparin; leaves open human validation before any clinical use.
Does recombinant hirudin alter platelet functions compared to heparin or citrate in anticoagulated blood?
Recombinant hirudin is a suitable anticoagulant for in vitro platelet function studies as it does not alter platelet reactions or ionized calcium concentrations.
Glusa et al. (2009) studied this question. Recombinant hirudin (r-hirudin) vs. Heparin or citrate was evaluated on Platelet aggregation and 14C-serotonin secretion. Recombinant hirudin is a suitable anticoagulant for studying platelet functions, causing significantly lower spontaneous platelet aggregation compared to heparin or citrate without altering reactions.
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