Key result
Microstimulation of LTF, RVLM, and PAG antidromically activates hypothalamic neurons with sympathetic nerve-related activity.
Population
39 pentobarbital sodium-anesthetized cats
Design
Preclinical
Authors
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Maps hypothalamic projections to brainstem sympathetic centers in animals; leaves open relevance to human cardiovascular autonomic regulation.
Hypothalamic neurons with sympathetic nerve-related activity project to multiple brainstem regions, including the LTF, RVLM, and PAG, to modulate sympathetic nerve discharge.
Susan M. Barman (1990) studied this question. Microstimulation of medullary lateral tegmental field, RVLM, and PAG was evaluated on Antidromic and synaptic activation of hypothalamic neurons. Microstimulation of the medullary lateral tegmental field, rostral ventrolateral medulla, and periaqueductal gray antidromically activated hypothalamic neurons with sympathetic nerve-related activity.
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