Key result
PEG-rHuMGDF improves 5-fluorouracil-induced thrombocytopenia without accelerating arterial intimal thickening in rats.
Why the study?
The effects of PEG-rHuMGDF on 5-fluorouracil-induced thrombocytopenia and intimal thickening after arterial injury were unclear.
Does PEG-rHuMGDF ameliorate 5-fluorouracil-induced thrombocytopenia without accelerating intimal thickening in balloon-injured rats?
Does PEG-rHuMGDF ameliorate 5-fluorouracil-induced thrombocytopenia without accelerating intimal thickening in balloon-injured rats?
PEG-rHuMGDF ameliorates chemotherapy-induced thrombocytopenia without worsening intimal thickening in a rat model of arterial injury.
Answers are grounded in this paper and cite their sources.
May warrant preclinical follow-up for chemotherapy thrombocytopenia; leaves open any impact on vascular remodeling in patients.
We examined whether pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) affected 5-fluorouracil-induced thrombocytopenia without inducing more severe intimal thickening after injury to rat carotid arteries. Rat carotid arteries were injured using a balloon catheter on day 0. 5-Fluorouracil (100 mg kg(-1)) or vehicle was intravenously administered on day 1 in balloon-injured rats. PEG-rHuMGDF (100 microg kg(-1)) or vehicle was intravenously administered once a day on days 1-5 to balloon-injured rats given 5-fluorouracil or vehicle. 5-Fluorouracil (100 mg kg(-1), i.v.) caused a significant decrease in the platelet count from day 3 and peaked on days 7-9 in balloon-injured rats. PEG-rHuMGDF (100 microg kg(-1), i.v.) reduced this decrease on days 9 and 11. The administration of PEG-rHuMGDF did not accelerate the intimal thickening of balloon-injured arteries in rats treated with 5-fluorouracil compared with control balloon-injured rats. PEG-rHuMGDF did not increase plasma tumour growth factor-beta1 (TGF-beta1) from days 0-9 in balloon-injured rats compared with control balloon-injured rats. These results suggest that PEG-rHuMGDF ameliorated 5-fluorouracil-induced thrombocytopenia without accelerating the intimal thickening of balloon-injured arteries.
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Harada et al. (2000) studied 5-fluorouracil-induced thrombocytopenia in balloon-injured rats. PEG-rHuMGDF vs. vehicle was evaluated on Platelet count and intimal thickening. PEG-rHuMGDF ameliorated 5-fluorouracil-induced thrombocytopenia without accelerating the intimal thickening of balloon-injured arteries in rats.
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