Prognostic Relevance of Tumor Localization in Patients with Synovial Sarcoma

ABS TRACT Objective: Synovial sarcoma, an aggressive subtype of soft tissue tumors, mainly occurs in young individuals.In patients with synovial sarcoma, the tumor is predominantly localized in the lower extremities, cases.The present study aimed to investigate the contribution of tumor localization to the prognosis of patients with synovial sarcoma and to determine the factors affecting patient survival.Material and Methods: We retrospectively analyzed the clinical data of 35 patients with synovial sarcoma who were treated at our clinic between February 2000 and October 2022.Overall survival (OS) and the factors affecting patient survival were investigated.Results: The primary site of tumor mass localization was the limb in 19 patients (54.3%) and an extrinsic site in 16 patients (45.7%).The most common extrinsic site of tumor mass localization was the lung in 22.9% patients, followed by intra-abdominal localization in 8.6% patients.Of the 35 patients, 88.6% patients had undergone surgery, and 34.3% patients had received adjuvant chemotherapy, namely the Ifosfamide-Mesna-Doxorubicin regimen.The median OS was 51.1 months.Tumor localization to the limb, presence of curative surgery, and an Eastern Cooperative Oncology Group performance status score of 0-1 were found to be the independent prognostic factors affecting the OS.Conclusion: In the present study, the survival rate of patients with tumor localization in the limb was higher than that of patients with tumor localization at an extrinsic site.Local recurrence and progression rates were lower with curative surgery.The prognosis of patients who could not be treated curatively was poor.