Key result
Retransplantation to original donor strain clears cardiac allograft C4d deposition within 5 days in rats.
Why the study?
Antibody-mediated rejection of cardiac transplants is correlated with C4d deposits and macrophage infiltrates, but the dynamics of C4d deposition and clearance in sensitized recipients are not fully understood.
Does C4d deposition correlate with alloantibody levels and rejection in a rat model of cardiac transplantation, and how quickly is it cleared?
Population
Lewis rats sensitized with blood transfusion from DA rats before cardiac transplantation
Comparison
Sensitized recipients with CsA immunosuppression vs unsensitized recipients
Design
Preclinical study using rat cardiac transplantation model
Follow-up
Up to 90 days
Authors
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C4d intensity tracks alloantibody levels and chronic vasculopathy in rat cardiac allografts; leaves open whether serial monitoring can guide human AMR management.
Does C4d deposition correlate with alloantibody levels and rejection in a rat model of cardiac transplantation, and how quickly is it cleared?
In a rat cardiac transplant model, C4d deposition extends throughout the arterial tree and correlates with alloantibodies, but is rapidly cleared within days upon retransplantation.
Minami et al. (2006) studied Cardiac transplantation and antibody-mediated rejection. Sensitization with blood transfusion vs. Unsensitized recipients was evaluated on C4d deposition and clearance. In a rat model of cardiac transplantation, C4d deposition extended throughout the arterial tree and was cleared within 5 days after retransplantation to the original donor strain.
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