Manual of gastroenterologic procedures

Q: What is the clinical evidence from this study?

Study design: Letter. Population: Endoscopic duodenitis (n=10). Intervention: De-Nol (colloidal bismuth) vs. Baseline. Primary outcome: Gastric bicarbonate output (p=NS).

Q: What does this research mean for the field?

Therapeutic treatment with De-Nol produces no sustained increase in gastric bicarbonate output in humans, indicating that stimulation of alkaline secretion does not explain its ulcer-healing properties. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

D S Rampton

doi:10.1136/gut.29.5.697

May 1, 1988GutOpen Access

Manual of gastroenterologic procedures

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Why the study?

The stimulatory effect of therapeutic doses of De-Nol on gastric alkaline secretion in man and its relevance to ulcer healing is uncertain.

Does De-Nol increase gastric bicarbonate output in patients with endoscopic duodenitis?

Structured PICO

Does De-Nol increase gastric bicarbonate output in patients with endoscopic duodenitis?

P

Population

10 patients with endoscopic duodenitis, devoid of gastric abnormalities and with normal basal bicarbonate secretion, treated for four weeks.

I

Intervention

De-Nol (colloidal bismuth) 600 mg bid for four weeks

C

Comparator

Baseline (before treatment)

O

Outcome

Gastric bicarbonate output (basal alkaline secretion) measured 10 hours after the last dosesurrogate

Main Result

p-value: p=NS

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Implication

Therapeutic doses of colloidal bismuth (De-Nol) do not significantly increase gastric alkaline secretion in humans, suggesting this is not its primary mechanism for ulcer healing.

Abstract

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Discussion

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Cite This Study

D S Rampton (1988) conducted a letter in Endoscopic duodenitis (n=10). De-Nol (colloidal bismuth) vs. Baseline was evaluated on Gastric bicarbonate output (p=NS).

synapsesocial.com/papers/6aaa1330247ec6c946482577 https://doi.org/10.1136/gut.29.5.697

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Manual of gastroenterologic procedures

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Manual of gastroenterologic procedures

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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