Key result
Dopexamine infusion significantly decreased intramucosal pH after 4 hours compared to placebo in patients undergoing valve replacement (P<0.05).
Why the study?
Does dopexamine infusion improve calculated intramucosal pH in adult patients undergoing valve replacement?
Population
18 adult patients undergoing valve replacement who developed a postoperative pHi > 7.30
Comparison
Dopexamine infusion (2 micrograms.kg-1 min-1) vs Placebo
Design
RCT, randomized, double blind
Follow-up
approximately 18 hours postoperatively
Authors
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Dopexamine worsens intramucosal pH after valve replacement; does not support splanchnic protection and challenges hypothesized perioperative benefit.
RCT (n=18)
Double-blind
randomized
Does dopexamine infusion improve calculated intramucosal pH in adult patients undergoing valve replacement?
p-value: p=<0.05
Dopexamine infusion significantly decreased intramucosal pH compared to placebo in patients after valve replacement, suggesting it does not improve splanchnic ischemia as measured by pHi.
Gårdebäck et al. (1995) conducted an RCT in valve replacement (n=18). dopexamine vs. placebo was evaluated on calculated intramucosal pH (pHi) (p=<0.05). Dopexamine infusion significantly decreased intramucosal pH after 4 hours compared to placebo in patients undergoing valve replacement (P<0.05).
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