Key result
Dopexamine infusion improved creatinine clearance (P<=0.025) and reduced systemic inflammation (IL-6, P<=0.02) without affecting splanchnic oxygenation in patients undergoing CABG.
Why the study?
Does dopexamine improve creatinine clearance, systemic inflammation, and splanchnic oxygenation in patients undergoing coronary artery bypass grafting?
Population
44 patients scheduled for coronary artery bypass grafting
Comparison
Continuous infusions of 0.5, 1.0, or 2… vs Placebo
Design
RCT, randomized
Follow-up
postoperative period
Authors
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Supports perioperative dopexamine for renal protection and reduced inflammation in CABG; challenges expectations of splanchnic oxygenation benefit.
RCT (n=44)
randomized
Does dopexamine improve creatinine clearance, systemic inflammation, and splanchnic oxygenation in patients undergoing coronary artery bypass grafting?
Perioperative dopexamine infusion in CABG patients improves creatinine clearance and attenuates systemic inflammation, though it does not alter splanchnic oxygenation.
Berendes et al. (1997) conducted an RCT in Coronary artery bypass grafting (n=44). Dopexamine vs. Placebo was evaluated on Hemodynamic parameters, creatinine clearance, systemic and splanchnic oxygenation, gastric mucosal pH, and inflammatory markers. Dopexamine infusion improved creatinine clearance (P<=0.025) and reduced systemic inflammation (IL-6, P<=0.02) without affecting splanchnic oxygenation in patients undergoing CABG.
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