Key result
Dopamine (4 µg/kg/min) and dopexamine (2 µg/kg/min) significantly increased liver blood flow after cardiopulmonary bypass by 76% and 38% respectively, with dopexamine showing no advantage over dopamine.
Why the study?
Does dopamine or dopexamine improve liver blood flow in patients undergoing elective coronary artery bypass graft surgery?
Population
30 patients undergoing elective coronary artery bypass graft surgery
Comparison
Dopamine or dopexamine infused 6 hours after… vs Placebo (dextrose 5%)
Design
RCT, randomized into three groups (n = 10 per group)
Follow-up
1 to 2 hours post-infusion
Authors
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Favors dopamine to augment post-CPB hepatic perfusion in elective CABG; challenges any superiority of dopexamine at tested doses.
RCT (n=30)
Randomized into three groups
Does dopamine or dopexamine improve liver blood flow in patients undergoing elective coronary artery bypass graft surgery?
Effect estimate: 76% increase with dopamine, 38% increase with dopexamine
Absolute Event Rate: 11.8% vs 7.9%
p-value: p=<0.05
Dopamine and dopexamine both increase liver blood flow after cardiopulmonary bypass, with dopexamine showing no advantage over dopamine.
SHARPE et al. (1999) conducted an RCT in Elective coronary artery bypass graft surgery (n=30). Dopamine and dopexamine vs. Placebo (dextrose 5%) was evaluated on Liver blood flow determined by the percentage disappearance rate of indocyanine green (76% increase with dopamine, 38% increase with dopexamine, p=<0.05). Dopamine (4 µg/kg/min) and dopexamine (2 µg/kg/min) significantly increased liver blood flow after cardiopulmonary bypass by 76% and 38% respectively, with dopexamine showing no advantage over dopamine.
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