Key result
Krasno-Ivy nitroglycerin-flicker fusion test proves clinically unreliable and lacks correlation with standard tests.
Why the study?
The clinical usefulness and reliability of the Krasno-Ivy nitroglycerin-flicker fusion test for early detection of heart disease tendency were uncertain.
Does the Krasno-Ivy nitroglycerin-flicker fusion test reliably detect heart disease tendency in normal persons and patients with cardiovascular disease?
Observational
Does the Krasno-Ivy nitroglycerin-flicker fusion test reliably detect heart disease tendency in normal persons and patients with cardiovascular disease?
The Krasno-Ivy nitroglycerin-flicker fusion test is unreliable and lacks clinical usefulness for the early detection of cardiovascular disease.
Answers are grounded in this paper and cite their sources.
Avoid Krasno-Ivy test for cardiovascular screening; leaves open validation of reliable noninvasive alternatives.
The Krasno-Ivy nitroglycerin-flicker fusion test was carried out in normal persons, and in patients with arterial hypertension and/or coronary disease. A positive test was obtained more often in patients with cardiovascular abnormalities than in normal individuals. In the former group the frequency of negative results and the inconstancy of response to multiple tests indicate the unreliability of this procedure for "the early detection of heart disease tendency." No correlation could be demonstrated between the results of the flicker fusion test, the Master two step or the cold pressor test. The evidence does not support the, alleged clinical usefulness of the nitroglycerin-flicker fusion test.
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Russek et al. (1951) conducted an observational in Arterial hypertension and/or coronary disease. Krasno-Ivy nitroglycerin-flicker fusion test vs. Normal individuals was evaluated on Positive test frequency and correlation with other tests. The Krasno-Ivy nitroglycerin-flicker fusion test yielded inconsistent responses and showed no correlation with the Master two step or cold pressor tests, indicating it is clinically unreliable.
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