Fatigue in patients with circulatory insufficiency cannot be fully explained by hemodynamics alone, prompting investigation into central nervous system fatigue using flicker fusion frequency.
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Fatigue in circulatory insufficiency may involve non-hemodynamic factors; hypothesis-generating for central mechanisms, requiring prospective validation.
Article1 April 1942FATIGUE OF PATIENTS WITH CIRCULATORY INSUFFICIENCY, INVESTIGATED BY MEANS OF THE FUSION FREQUENCY OF FLICKERNORBERT ENZER, M.D., F.A.C.P., ERNST SIMONSON, M.D., SAMUEL S. BLANKSTEIN, M.D.NORBERT ENZER, M.D., F.A.C.P., ERNST SIMONSON, M.D., SAMUEL S. BLANKSTEIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-4-701 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients with circulatory insufficiency from heart disease and hypertension fatigue easily, not only in heavy or moderate muscular work, but also in types of light muscular work, in mental work and even in resting condition. This cannot be explained by the circulatory insufficiency alone; the increase of the oxygen consumption during those types of work is very slight, and these patients are still able to increase the cardiac minute volume more than would be necessary to cover the slightly increased demands for oxygen consumption and transportation.This question has some practical significance. There are several million cardiac patients with slight...Bibliography1. HEYMANSBOUCKAERTJOURDANNOWAKFARBER CIIFIGS: Survival and revival of nerve centers following acute anemia, Arch. Neurol., 1937, xxxviii, 304. CrossrefGoogle Scholar2. SIMPSONDERBYSHIRE HNAJ: Electrical activity of the motor cortex during cerebral anemia, Am. Jr. Physiol., 1934, cix, 99. Google Scholar3. SUGARGERARD ORW: Anoxia and brain potentials, Jr. Neurophysiol., 1938, i, 558. CrossrefGoogle Scholar4. WOLFF HG: The cerebral circulation, Physiol. Rev., 1936, xvi, 545. CrossrefGoogle Scholar5. QUESTAL EG: Respiration in the central nervous system, Physiol. Rev., 1939, xix, 135. CrossrefGoogle Scholar6. SIMONSONENZER EN: Measurement of fusion frequency of flicker as a test for fatigue of the central nervous system, Jr. Indust. Hyg., 1941, xxiii, 83-89. Google Scholar7. CROZIER WJ: On the sensory discrimination of intensities, Proc. Nation. Acad. Sci., 1936, xxii, 412. CrossrefGoogle Scholar8. HECHT S: The nature of the visual process, Bull. New York Acad. Med., 1938, xiv, 21. Google Scholar9. DUKE-ELDER W: Textbook of ophthalmology, 1932, C. V. Mosby Co., St. Louis, Vol. I., p. 459. Google Scholar10. RIDDELL AL: Use of flicker phenomenon in investigation of field of vision, Brit. Jr. Ophth., 1936, xx, 385. CrossrefGoogle Scholar11. ALTSCHULE MD: Chronic cardiac decompensation, Medicine, 1938, xvii, 75. CrossrefGoogle Scholar12. WIGGERS CJ: Physiologic meaning of common clinical signs and symptoms in cardiovascular disease, Jr. Am. Med. Assoc., 1931, xcvi, 603. CrossrefGoogle Scholar13. SIMONSONENZERBLANKSTEIN ENS: The influence of age on the fusion frequency of flicker, Jr. Exper. Psychol., 1941, xxix, 252. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Milwaukee, Wisconsin*Received for publication February 8, 1941.From the Research Laboratory of the Mount Sinai Hospital, Milwaukee, Wisconsin. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVisual Cue in the Peripheral Vision Field for a Driving Support SystemBlood Pressure and Cognition in the Aberdeen 1936 Birth CohortDifferential cognitive outcomes in the Hypertensive Old People in Edinburgh studyHypertension: Cognitive and behavioral considerationsNeuropsychological Effects of Antihypertensive DrugsQ-technique methodology in the study of healthy aged men (part II)Slowing of response time in young and middle-aged hypertensive patientsDiscrimination learning in mice genetically selected for high and low blood pressure: Initial findings and methodological implicationsIntelligence and Blood Pressure in the AgedRussian research on cardiac compensation and decompensationThe Flicker Fusion Threshold and its Response to Nitroglycerin in Hypertension and in Coarctation of the AortaThe Fusion Frequency of Flicker as A Criterion of Central Nervous System Fatigue*FLICKER FUSION IN CEREBRAL HYPOXIA: Introductory lecture given at the Thirteenth Scandinavian Neurological Congress, Lund, June 1955Flicker-Fusion Frequency and Hypertension*A 16mm Projector for Research FilmsFlicker fusion nitroglycerin tests in normal young adultsFlicker fusion thresholds in pregnancyThe fusion frequency of flicker in hypertensionStudies in the Arctic with the Flicker-Fusion Nitroglycerin TestThe Flicker Fusion Frequency and Its Response to Nitroglycerin in Normal Subjects and in Patients with Cardiovascular DiseaseThe Nitroglycerin-Flicker TestA New Electronic Apparatus for the Measurement of the Fusion Frequency of Flicker 1 April 1942Volume 16, Issue 4Page: 701-707KeywordsCardiovascular therapyFatigueHypertensionOxygen consumptionResearch laboratories ePublished: 1 December 2008 Issue Published: 1 April 1942 PDF downloadLoading ...
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