Key result
Rapid aggressive surgery fails to prevent death in diffuse leg angiosarcoma with chronic idiopathic lymphedema.
Why the study?
Angiosarcoma arising from idiopathic lymphedema of the lower extremity is extremely rare and not well characterized.
Case Report (n=1)
This case highlights the extremely rare occurrence of Stewart-Treves syndrome (angiosarcoma) arising from idiopathic lymphedema of the lower extremity, which carries a very poor prognosis despite aggressive surgery.
Underscores lethal course of angiosarcoma in idiopathic lymphedema; extends sparse literature on this rare syndrome and its management challenges.
Angiosarcoma arising from chronic lymphedema is referred to as Stewart-Treves syndrome. It typically occurs as a complication of long-lasting lymphedema of the arm after mastectomy and/or radiotherapy for breast cancer. Angiosarcoma associated with idiopathic lymphedema of the lower extremity is extremely rare. We report a case of diffuse angiosarcoma of the leg in a patient with a 25-year history of idiopathic lymphedema. Despite rapid aggressive surgical treatment, the patient died 6 weeks after diagnosis.
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Komorowski et al. (2003) conducted a case report in Stewart-Treves syndrome (angiosarcoma associated with idiopathic lymphedema) (n=1). Rapid aggressive surgical treatment was evaluated on Mortality. Rapid aggressive surgical treatment did not prevent death, which occurred 6 weeks after diagnosis in a patient with diffuse angiosarcoma of the leg and chronic idiopathic lymphedema.
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