Key result
Multimodal therapy combining hyperthermic limb perfusion and radical resection may improve secondary angiosarcoma survival.
Why the study?
Secondary angiosarcoma (Stewart-Treves Syndrome) is a rare malignant cutaneous lesion arising in chronic lymphedema of the extremity.
Does multimodal therapy including hyperthermic isolated limb perfusion and radical resection improve survival in patients with Secondary Angiosarcoma?
Case Report (n=2)
Does multimodal therapy including hyperthermic isolated limb perfusion and radical resection improve survival in patients with Secondary Angiosarcoma?
Multimodal therapy including hyperthermic isolated limb perfusion and radical resection may improve survival in the rare Stewart-Treves Syndrome.
Hypothesis-generating for multimodal therapy in rare secondary angiosarcoma; prospective trials needed before practice change.
Secondary Angiosarcoma (Stewart-Treves Syndrome) is a rare malignant cutaneous lesion, which arises in chronic lymphedema of the extremity, often observed after breast cancer treatment. We reviewed the history and the oncological outcome of two patients with this disease. Multimodal therapy including hyperthermic isolated limb perfusion with TNF-alpha and Melphalan, combined with radical resection of the affected skin and subcutaneous tissue including the fascia, with large safety margins may probably lead to better survival.
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Farzaliyev et al. (2019) conducted a case report in Secondary Angiosarcoma (Stewart-Treves Syndrome) (n=2). Multimodal therapy including hyperthermic isolated limb perfusion with TNF-alpha and Melphalan, combined with radical resection was evaluated on Oncological outcome and survival. Multimodal therapy including hyperthermic isolated limb perfusion with TNF-alpha and Melphalan, combined with radical resection, may lead to better survival in secondary angiosarcoma.
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