Using Variable Flip Angle (VFA) and Modified Look-Locker Inversion Recovery (MOLLI) T1 mapping in clinical OE-MRI

Emma Bluemke; Ambre Bertrand; Kwun-Ye Chu; Nigar Syed; Andrew G. Murchison; Rosie Cooke; Tessa Greenhalgh; Brian Burns; Martin Craig; Nia Taylor; Ketan Shah; Fergus Gleeson; Daniel P. Bulte

doi:10.1016/j.mri.2022.03.001

March 24, 2022Magnetic Resonance ImagingOpen Access

Using Variable Flip Angle (VFA) and Modified Look-Locker Inversion Recovery (MOLLI) T1 mapping in clinical OE-MRI

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Key Points

To evaluate the practical feasibility, image artifacts, and quantitative performance of Variable Flip Angle (VFA) versus Modified Look-Locker Inversion Recovery (MOLLI) T1 mapping in clinical oxygen-enhanced MRI for oropharyngeal tumors.
Implemented both VFA and MOLLI T1 mapping protocols within an oxygen-enhanced MRI (OE-MRI) clinical study of oropharyngeal squamous cell carcinoma.
Evaluated practical imaging challenges, quantified differences in baseline T1 estimation and region of interest (ROI) standard deviations, and synthesized acquisition parameters from over 45 published manuscripts.
VFA produced baseline T1 estimations that were on average 27% higher than those obtained using MOLLI.
Tumor region of interest standard deviations did not differ significantly between VFA and MOLLI, but VFA proved practically superior for clinical OE-MRI in tumors.

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Implication

Comparative clinical study finds variable flip angle T1 mapping outperforms MOLLI during oxygen-enhanced MRI in oropharyngeal cancer, highlighting better protocols for tumor hypoxia imaging.

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Bluemke et al. (2022) studied this question.

synapsesocial.com/papers/6aaa1e7a71e43eb1ac558d6a https://doi.org/10.1016/j.mri.2022.03.001

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Using Variable Flip Angle (VFA) and Modified Look-Locker Inversion Recovery (MOLLI) T1 mapping in clinical OE-MRI

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Using Variable Flip Angle (VFA) and Modified Look-Locker Inversion Recovery (MOLLI) T1 mapping in clinical OE-MRI

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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