Key result
Flavored ENDS drive action potential instability and inducible ventricular arrhythmias in mice and cell lines.
Why the study?
Electronic nicotine delivery systems are not harm-free, but whether they negatively affect cardiac electrophysiological function is unknown.
Do flavored electronic nicotine delivery systems (ENDS) affect cardiac electrophysiological function in cell lines and mice?
Do flavored electronic nicotine delivery systems (ENDS) affect cardiac electrophysiological function in cell lines and mice?
Flavored electronic nicotine delivery systems demonstrate in vitro and in vivo cardiac toxicity by compromising electrophysiology and inducing ventricular arrhythmias in preclinical models.
Raises arrhythmia concerns with ENDS; hypothesis-generating and requires human studies before clinical relevance.
The use of electronic nicotine delivery systems (ENDS) is not harm free. It is not known whether ENDS negatively affect cardiac electrophysiological function. Our study in cell lines and in mice shows that ENDS can compromise cardiac electrophysiology, leading to action potential instability and inducible ventricular arrhythmias. Further investigations are necessary to assess the long-term cardiac safety profile of ENDS products in humans and to better understand how individual components of ENDS affect cardiac toxicity.
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Abou-Assali et al. (2020) studied this question. Flavored electronic nicotine delivery systems (ENDS) was evaluated on Cardiac electrophysiology, action potential instability, and inducible ventricular arrhythmias. Exposure to flavored electronic nicotine delivery systems compromised cardiac electrophysiology in cell lines and mice, leading to action potential instability and inducible ventricular arrhythmias.
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