Key result
Higher nHDLox linked to ~67% greater HFpEF risk per SD.
Why the study?
While dysfunctional HDL has been associated with heart failure, the specific link between oxidized HDL and heart failure remains unexplored.
Is reduced HDL antioxidant function associated with the presence of heart failure with preserved ejection fraction (HFpEF) in patients with suspected heart failure?
Population
366 patients with suspected heart failure
Comparison
Participants with HFpEF vs those without heart failure
Design
Cross-sectional observational study
Authors
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May link HDL oxidative dysfunction to HFpEF; hypothesis-generating for targeted therapies, pending prospective validation.
Cross-Sectional (n=268)
No
Is reduced HDL antioxidant function associated with the presence of heart failure with preserved ejection fraction (HFpEF) in patients with suspected heart failure?
Odds Ratio: 1.67 (95% CI 1.07–2.6)
p-value: p=0.02
Reduced HDL antioxidant function is independently associated with HFpEF, highlighting a potential pathophysiological role of oxidative stress and a novel therapeutic target in this population.
Sasko et al. (2025) conducted a cross-sectional in Heart failure with preserved ejection fraction (HFpEF) (n=268). Normalized HDL-lipid peroxide content (nHDLox) vs. Participants without heart failure was evaluated on Presence of HFpEF (OR 1.67, 95% CI 1.07-2.6, p=0.02). A 1-SD increase in normalized HDL-lipid peroxide content (nHDLox) was associated with a 67% increased risk for heart failure with preserved ejection fraction compared to participants without heart failure.
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