Key result
Power genotypes linked to greater walking speed gains after power training in older women.
Why the study?
The influence of ACE I/D and ACTN3 R577X polymorphisms on lower-extremity function response to high-speed power training in older women was unclear.
Do ACE I/D and ACTN3 R577X polymorphisms influence lower-extremity function improvements in older women in response to high-speed power training?
Comparison
Genotype groups based on ACE I/D and ACTN3 R577X polymorphisms
Design
Cohort study with genotyping and repeated-measures analysis
Follow-up
12 weeks
Authors
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Genotype may guide power training responses for gait in older women; hypothesis-generating and requires prospective validation before practice change.
Cohort (n=139)
No
Do ACE I/D and ACTN3 R577X polymorphisms influence lower-extremity function improvements in older women in response to high-speed power training?
p-value: p=0.048
ACE I/D and ACTN3 R577X polymorphisms may modulate exercise-related gait speed improvements in older women undergoing high-speed power training.
Pereira et al. (2013) conducted a cohort in Healthy older women (n=139). ACE I/D and ACTN3 R577X polymorphisms vs. Non-power genotypes (ACTN3 XX & ACE II + ID) was evaluated on Walking speed (S10) performance (p=0.048). The combination of 'power' genotypes (ACTN3 RR + RX and ACE DD) was associated with significantly greater improvements in walking speed following 12 weeks of high-speed power training compared to 'non-power' genotypes in older Caucasian women.
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