Answers are grounded in this paper and cite their sources.
Animal study reveals elevated eosinophil counts in lymphoma-bearing rats stem from prolonged intravascular survival rather than overproduction, suggesting tumor cells block tissue emigration pathways.
Summary Inbred rats developed an increased blood eosinophil count 2 weeks after injection of syngeneic or semi‐syngeneic lymphoma cells. An eosinophilia did not occur in allogeneic recipients. Autoradiographic studies of bone marrow eosinophil production showed that additional eosinophils were not being made, and tissue eosinophil levels were also normal. Moreover injections of prednisolone did not lower blood eosinophil counts significantly in the rats with the lymphoma. Other experiments showed that the eosinophilia was probably not due to a graft‐versus‐host reaction. It was concluded that the mechanism of eosinophilia was a prolongation of eosinophil survival in the blood, possibly due to blockage of normal emigration pathways into tissues, by large numbers of blood‐borne lymphoma cells.
No takes yet. Share an insight, caveat, or question.
Christopher J. F. Spry (1972) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: