Key result
Estrogen and vitamin E similarly improve vasodilator responsiveness, but only estrogen reduces vascular disease markers.
Why the study?
Comparison of the vascular effects of estrogen and vitamin E therapies to determine mechanisms of potential cardiovascular benefit had not been performed in postmenopausal women.
Do conjugated equine estrogens, vitamin E, or their combination improve vascular function and markers of vascular disease in healthy postmenopausal women?
RCT (n=28)
Double-blind
randomly assigned
Do conjugated equine estrogens, vitamin E, or their combination improve vascular function and markers of vascular disease in healthy postmenopausal women?
p-value: p=0.267
Both estrogen and vitamin E improve endothelial function in healthy postmenopausal women, but only estrogen favorably alters atherogenic lipoproteins and inflammatory markers.
No takes yet. Share an insight, caveat, or question.
Both estrogen and vitamin E improve endothelial function, yet only estrogen improves lipids; extends differential vascular effects of hormone therapy in postmenopausal women.
Koh et al. (1999) conducted an RCT in healthy postmenopausal women (n=28). Conjugated equine estrogens (CE) and vitamin E vs. Pretreatment values / each other was evaluated on Brachial artery flow-mediated dilation (p=0.267). Estrogen and vitamin E therapies similarly improved arterial endothelium-dependent vasodilator responsiveness (P=0.267 between therapies), but only estrogen reduced markers of vascular disease.
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