Why the study?
Does conjugated equine estrogen, simvastatin, or their combination improve endothelium-dependent vasomotor responsiveness in hypercholesterolemic postmenopausal women?
Population
28 hypercholesterolemic postmenopausal women
Comparison
Conjugated equine estrogen 0.625 mg, simvastatin… vs Baseline values and cross-comparison between the…
Design
RCT, randomly assigned
Follow-up
6 weeks
Authors
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Estrogen may confer additive benefits on fibrinolysis and inflammation; extends evidence distinguishing hormone from statin vascular effects in hypercholesterolemic postmenopausal women.
Does conjugated equine estrogen, simvastatin, or their combination improve endothelium-dependent vasomotor responsiveness in hypercholesterolemic postmenopausal women?
Estrogen and simvastatin similarly improve endothelium-dependent vasodilation in hypercholesterolemic postmenopausal women, but estrogen uniquely improves markers of fibrinolysis and vascular inflammation.
Koh et al. (1999) studied this question.
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