High Lipoprotein(a) and Low Risk of Major Bleeding in Brain and Airways in the General Population: a Mendelian Randomization Study
Key result
High Lp(a) linked to ~16% lower risk of major brain and airway bleeding.
- HR 0.84
- 95% CI 0.71-0.99
- n=109,169
Why the study?
The physiological role of lipoprotein(a) is unclear, but it may influence hemostasis and wound healing, motivating investigation of its association with major bleeding risk.
Are high lipoprotein(a) concentrations associated with a lower risk of major bleeding in the brain and airways in the general population?
Population
109,169 individuals from the Danish general population
Comparison
High lipoprotein(a) concentrations vs low lipoprotein(a) concentrations
Design
Prospective observational cohort study with genetic analyses
Authors
Discussion
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Member takes
Implication
High Lp(a) linked to lower bleeding risk in cohort; hypothesis-generating for hemostasis, needs prospective validation.
Study Design
Type
Observational (n=109,169)
Multicenter
Yes
Structured PICO
Are high lipoprotein(a) concentrations associated with a lower risk of major bleeding in the brain and airways in the general population?
P
Population
109,169 individuals from two prospective Danish general population cohorts assessed for lipoprotein(a) concentrations and genetic variants.
E
Exposure
High lipoprotein(a) concentrations (measured observationally and genetically via LPA KIV-2 repeats and rs10455872)
C
Comparator
Low lipoprotein(a) concentrations (e.g., <110 mg/L, >35 KIV-2 repeats, rs10455872 noncarriers)
O
Outcome
Major bleeding in the brain and airways (hospital contacts or death)hard clinical
Main Result
Hazard Ratio: 0.84 (95% CI 0.71–0.99)
High lipoprotein(a) concentrations are observationally and causally associated with a lower risk of major bleeding in the brain and airways, suggesting a role in hemostasis and wound healing.
Cite This Study
Langsted et al. (2017) conducted an observational in General population (n=109,169). High lipoprotein(a) concentrations vs. Low lipoprotein(a) concentrations was evaluated on Major bleeding in the brain and airways (HR 0.84, 95% CI 0.71-0.99). High lipoprotein(a) concentrations (>800 mg/L vs <110 mg/L) were associated with a lower risk of major bleeding in the brain and airways (HR 0.84; 95% CI 0.71-0.99).