Key result
Small LPA isoform size is linked to ~25% higher Alzheimer's risk despite no Lp(a) concentration association.
Why the study?
Are lipoprotein(a) levels associated with the risk of Alzheimer's disease or vascular-related dementia in the general population?
Population
539,478 individuals from the Copenhagen General Population Study, the Copenhagen City Heart Study, and the…
Comparison
Lipoprotein levels and LPA kringle IV type 2… vs Lower lipoprotein levels or >50th percentile LPA…
Design
Cohort
Follow-up
up to 30.2 years
Authors
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Low lipoprotein(a) levels are not associated with the risk of Alzheimer's disease or vascular-related dementia, though very high levels or small isoform size may increase risk.
Cohort (n=539,478)
Yes
Are lipoprotein(a) levels associated with the risk of Alzheimer's disease or vascular-related dementia in the general population?
Hazard Ratio: 1.25 (95% CI 1.06–1.46)
Low lipoprotein(a) levels are not associated with the risk of Alzheimer's disease or vascular-related dementia, though very high levels or small isoform size may increase risk.
Thomas et al. (2025) conducted a cohort in Dementia (Alzheimer's disease and vascular-related dementia) (n=539,478). Lipoprotein(a) levels and LPA KIV-2 number of repeats vs. Lower lipoprotein(a) levels or >50th percentile LPA KIV-2 repeats was evaluated on Alzheimer's disease and vascular-related dementia (HR 1.25, 95% CI 1.06-1.46). Lipoprotein(a) levels were not associated with dementia risk on continuous scales, but small isoform size (LPA KIV-2 repeats ≤5th vs >50th percentiles) increased Alzheimer's risk (HR 1.25; 95% CI 1.06-1.46).
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