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December 7, 2021Open Access

Key Time Points After Bariatric Surgery, From Weight Loss To Weight Regain: Long-Term Retrospective Cohort Study

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Key result

One anastomosis gastric bypass shows ~78% excess weight loss at 60 months, beating RYGB and LSG.

  • P<0.001
  • n=2,567

Why the study?

Long-term results after bariatric surgery and repetitive weight fluctuations remain unclear, with potential for unsuccessful weight loss, plateaus, and weight regain.

How do different types of bariatric surgery (LSG, RYGB, OAGB) compare in terms of long-term weight loss and weight regain over 5 years in morbidly obese patients?

Population

2567 morbidly obese participants at a specialized obesity clinic

Comparison

LSG vs RYGB vs OAGB

Design

Retrospective cohort study

Follow-up

Up to five years

Authors

MHMahsa HatamiAPAbdolreza PazoukiFHFatemeh Sadat Hosseini‐Baharanchi

Discussion

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Member takes

Overview

May support OAGB preference in observational cohorts; leaves open need for RCTs to confirm durability and safety.

Study Design

Type

Cohort (n=2,567)

Multicenter

No

Structured PICO

How do different types of bariatric surgery (LSG, RYGB, OAGB) compare in terms of long-term weight loss and weight regain over 5 years in morbidly obese patients?

P
Population
2,567 patients with morbid obesity (mean age 39 years, 64% female) who underwent bariatric surgery, followed for up to 5 years to evaluate weight loss and regain.
E
Exposure
Bariatric surgery (laparoscopic sleeve gastrectomy [LSG], Roux-en-Y gastric bypass [RYGB], or one anastomosis gastric bypass [OAGB])
C
Comparator
Comparison between the three types of surgery (LSG, RYGB, OAGB)
O
Outcome
Key time points of weight changes and estimation of five-year weight loss (%EWL)surrogate

Main Result

Absolute Event Rate: 77.6% vs 65.55%

p-value: p=<0.001

OAGB provides the fastest and highest percentage of excess weight loss compared to RYGB and LSG, with LSG showing the earliest and most significant weight regain over 5 years.

Limitations

  • Retrospective study design
  • Estimation of five-year %EWL was based on the mean of %EWL in a total of participants, which may not be accurately generalizable to individuals
  • Lack of data on potential confounders including lifestyle, socioeconomic factors, dietary pattern, smoking, alcohol, psychiatric status, and physical activity
  • 34% lost to follow-up until five-year after surgery

Cite This Study

Hatami et al. (2021) conducted a cohort in Morbid obesity (n=2,567). One anastomosis gastric bypass (OAGB) vs. Roux-en-Y gastric bypass (RYGB) and laparoscopic sleeve gastrectomy (LSG) was evaluated on Percentage of excess weight loss (%EWL) at 60 months (p=<0.001). One anastomosis gastric bypass provided the highest percentage of excess weight loss at 60 months (77.6%) compared to Roux-en-Y gastric bypass (65.6%) and laparoscopic sleeve gastrectomy (57.1%).

synapsesocial.com/papers/6aaa3f83cb4848aa8fe9deechttps://doi.org/10.21203/rs.3.rs-1064596/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-Term Weight Loss and Metabolic Syndrome Remission after Bariatric Surgery: The Effect of Sex, Age, Metabolic Parameters and Surgical Technique – A 4-Year Follow-Up Study2019 · 66 citations
  2. 2British Obesity and Metabolic Surgery Society Guidelines on perioperative and postoperative biochemical monitoring and micronutrient replacement for patients undergoing bariatric surgery—2020 update2020 · 336 citations
  3. 3Suboptimal Weight Loss and Weight Regain after Gastric Bypass Surgery—Postoperative Status of Energy Intake, Eating Behavior, Physical Activity, and Psychometrics2016 · 109 citations
  4. 4Early postoperative weight loss predicts maximal weight loss after sleeve gastrectomy and Roux-en-Y gastric bypass2014 · 141 citations
  5. 5Weight Loss Medications in Young Adults after Bariatric Surgery for Weight Regain or Inadequate Weight Loss: A Multi-Center Study2018 · 58 citations