Key result
His-bundle pacing upgrade linked to improved EF and functional status in CHF with chronic AF.
Why the study?
Single-chamber ICDs do not regularize heart rate in chronic AF and often limit optimal beta-blocker dosing due to right ventricular pacing risks.
Does direct His-bundle pacing via upgrade to dual-chamber ICD improve echocardiographic parameters and functional status in patients with CHF and chronic AF?
Observational (n=39)
Does direct His-bundle pacing via upgrade to dual-chamber ICD improve echocardiographic parameters and functional status in patients with CHF and chronic AF?
Upgrading from a single-chamber to a dual-chamber ICD to provide direct His-bundle pacing significantly improves ejection fraction and functional status in patients with CHF and chronic AF.
May support His-bundle pacing upgrades in CHF with chronic AF; hypothesis-generating and requires randomized confirmation before practice change.
A single-chamber ICD is a standard method for primary SCD prophylaxis. In patients with chronic atrial fibrillation it does not contribute to the regularization of heart rate, which is crucial for proper treatment. Moreover, to avoid the deleterious effect of right ventricular pacing only minority of the patients with single chamber ICD get the appropriate, recommended dose of beta-blockers. The aim of our study was to assess the efficacy of direct His-bundle pacing in a population of patients with congestive heart failure and chronic atrial fibrillation using upgrade from single chamber to dual-chamber ICD and atrial channel to perform the His-bundle pacing Methods The study population included 39 patients (37 men, 2 women) aged 67.2±9.3 years, with CHF and chronic AF implanted primarily with single chamber ICD with established pharmacotherapy and stable clinical status. Results The echocardiography measurements at baseline and during follow-up were presented in the table: During short period (3–6 months) of follow-up the mean values of EF and LV dimensions significantly improved. This was also accompanied by functional status improvement. Conclusions His-bundle-based pacing in CHF-chronic AF patients contributes to significant echocardiographic and clinical improvement. Standard single-chamber ICD implantation in CHF-chronic AF patients yields only SCD prevention without influence on remodeling process. The physiological pacing contributes to better pharmacotherapy.
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Ciesielski et al. (2020) conducted an observational in Congestive heart failure and chronic atrial fibrillation (n=39). His-bundle pacing via upgrade from single-chamber to dual-chamber ICD vs. Baseline (pre-upgrade) was evaluated on Echocardiography measurements (EF and LV dimensions) and functional status. His-bundle pacing via upgrade to a dual-chamber ICD in patients with CHF and chronic AF significantly improved ejection fraction, left ventricular dimensions, and functional status at 3-6 months.
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