Key result
Complex I disassembly impairs mitochondrial respiration in stroke-prone versus stroke-resistant hypertensive rats on high-salt diets.
Why the study?
Mitochondrial dysfunction underlying increased susceptibility to cerebrovascular disease in hypertension was previously detected but not studied at the molecular level.
Mitochondrial supercomplex association linked to Complex I dynamics and stability protects against stroke manifestation in a hypertensive rat model.
May guide mitochondrial research in hypertensive stroke models; leaves open human translation of CI disassembly.
The role of mitochondrial dysfunction underlying increased susceptibility to cerebrovascular disease in hypertension, previously detected in stroke-prone spontaneously hypertensive rats (SHR-SP) fed with a high-salt stroke-permissive Japanese-style diet (JD), was studied for the first time at the molecular level. The Complex I (CI) (dis)assembly in the supramolecular organization of respiratory supercomplexes (SCs) has emerged as the main component impairing the kinetic activity and SCs organization of mitochondrial respiration in SHR-SP compared with the SHR-stroke resistant (SR) strain upon the same dietary condition. The leak of substrate channeling and SCs arrangement in CI-dependent NADH oxidation in JD-fed SHR-SP was not detected in SHR-SR upon the same dietary regimen. Our results highlight that SCs association linked to CI dynamic and stability protects from stroke manifestation.
No takes yet. Share an insight, caveat, or question.
Cugliari et al. (2025) studied Hypertension-related stroke susceptibility. Stroke-prone spontaneously hypertensive (SHR-SP) strain vs. SHR-stroke resistant (SR) strain was evaluated on Complex I (dis)assembly and supramolecular organization of respiratory supercomplexes. Complex I disassembly in respiratory supercomplexes impairs mitochondrial respiration in stroke-prone spontaneously hypertensive rats compared with stroke-resistant strains on a high-salt diet.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: