Key result
In spontaneously hypertensive rats, the incidence of stroke was associated with stroke-prone gene concentration rather than the level of blood pressure, with salt accelerating stroke onset.
Population
Stroke-prone spontaneously hypertensive rats, stroke-resistant SHR, their hybrids, backcrosses (BC, BC), and…
Comparison
1% salt solution in drinking water vs Standard drinking water and different genetic…
Design
Preclinical
Authors
Loading...
Genetic factors may outweigh BP in stroke risk among hypertensive rat models; leaves open translation to human risk stratification.
In spontaneously hypertensive rats, genetic factors strongly determine stroke risk independently of blood pressure levels.
Nagaoka et al. (1976) studied Hypertension and stroke. Genetic predisposition (A3-gene concentration) and 1% salt solution vs. Stroke-resistant SHR (C) / normal Wistar-Kyoto rats / regular drinking water was evaluated on Blood pressure and incidence of stroke. In spontaneously hypertensive rats, the incidence of stroke was associated with stroke-prone gene concentration rather than the level of blood pressure, with salt accelerating stroke onset.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: