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December 1, 1999Journal of Hypertension

Differential brain atrial natriuretic peptide expression co-segregates with occurrence of early stroke in the stroke-prone phenotype of the spontaneously hypertensive rat

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Key result

Downregulation of brain atrial natriuretic peptide in the stroke-prone phenotype co-segregated with the occurrence of early strokes in F2 rats independently of blood pressure levels.

Population

32 male rats

Comparison

Stroke-permissive Japanese-style diet starting… vs Comparison between early vs late stroke…

Design

Preclinical

Authors

SRSperanza RubattuIstituto Neurologico MediterraneoRGRosangela GilibertiIstituto Neurologico MediterraneoUGUrsula GantenHeidelberg University

Discussion

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Implication

No immediate clinical implications; leaves open a causal genetic role for brain ANP in stroke susceptibility.

Structured PICO

P
Population
32 male rats (8 stroke-prone spontaneously hypertensive rats [SHRsp], 8 stroke-resistant SHR [SHRsr], and 16 SHRsp/SHRsr F2-intercross animals)
I
Intervention
Stroke-permissive Japanese-style diet starting at 6 weeks of age
C
Comparator
Comparison between early vs late stroke occurrence and between SHRsp vs SHRsr phenotypes
O
Outcome
Brain atrial natriuretic peptide (ANP) expression and its co-segregation with stroke occurrencesurrogate

Lower brain ANP expression in stroke-prone rats co-segregates with early stroke occurrence but is likely an inhibitory effect of other genes rather than a primary protective mechanism.

Cite This Study

Rubattu et al. (1999) studied Stroke (n=32). Stroke-permissive Japanese-style diet was evaluated on Co-segregation of brain ANP downregulation with early stroke occurrence. Downregulation of brain atrial natriuretic peptide in the stroke-prone phenotype co-segregated with the occurrence of early strokes in F2 rats independently of blood pressure levels.

synapsesocial.com/papers/6a0cf72a9a55ebeaa30cea52https://doi.org/10.1097/00004872-199917121-00011

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epidemiologic assessment of the role of blood pressure in stroke. The Framingham study1970 · 707 citations
  2. 2Altered Structure, Regulation, and Function of the Gene Encoding the Atrial Natriuretic Peptide in the Stroke-Prone Spontaneously Hypertensive Rat1999 · 61 citations
  3. 3Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage.1995 · 196 citations
  4. 4Distribution and characterization of immunoreactive adrenomedullin in human tissue and plasma1994 · 585 citations
  5. 5Familial incidence of cerebrovascular disease.1971 · 34 citations