Key result
Statin premedication is linked to less radial diastolic strain rate decline after ergonovine provocation.
Why the study?
Persistence of regional diastolic dysfunction after ischemic insult remains debatable and the effect of statin treatment on this dysfunction is unclear.
Does statin premedication prevent persistent regional diastolic dysfunction after ergonovine-provoked myocardial ischemia in patients with variant angina?
Comparison
Statin premedication vs no statin premedication
Design
Observational cohort study using speckle tracking echocardiography
Follow-up
1 day
Authors
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May aid differentiation of ischemic chest pain via STE in VA; leaves open confirmation, statin effects, and clinical adoption pending larger studies.
Observational (n=31)
Does statin premedication prevent persistent regional diastolic dysfunction after ergonovine-provoked myocardial ischemia in patients with variant angina?
p-value: p=0.003
Speckle tracking echocardiography can detect persistent regional diastolic dysfunction following transient ischemia, an effect that appears to be attenuated by prior statin therapy.
Kim et al. (2010) conducted an observational in Variant angina and myocardial ischemia (n=31). Statin premedication vs. No statin premedication was evaluated on Radial diastolic strain rate (rSRdia) 1 day after coronary angiography (p=0.003). Variant angina patients demonstrated a significant decrease in radial diastolic strain rate 1 day after ergonovine provocation (P=0.003), an effect that was minimized by statin premedication.
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