Key result
Long-term exercise training reduces mortality and cardiac events while improving quality of life in chronic HF.
Why the study?
The effect of long-term exercise training on all-cause mortality, cardiac events, and quality of life in patients with chronic heart failure was uncertain.
In patients with chronic heart failure, can long-term exercise training reduce all-cause mortality and cardiac events and improve quality of life?
RCT (n=99)
unblinded
randomized
No
In patients with chronic heart failure, can long-term exercise training reduce all-cause mortality and cardiac events and improve quality of life?
Long-term exercise training in patients with stable chronic heart failure reduces mortality and cardiac events while improving quality of life.
May support exercise in chronic HF; leaves open causal confirmation in randomized trials.
Exercise training for patients with chronic heart failure reduced mortality and cardiac events and improved quality of life QUESTIONIn patients with chronic heart failure, can long-term exercise training reduce all-cause mortality and cardiac events and improve quality of life?DESIGN A randomized, unblinded, controlled trial with a mean follow-up of 3.4 years. SETTING A cardiology institute and hospital in Italy. PATIENTSA total of 110 patients with stable chronic heart failure were screened, and 99 (mean age, 55 years; 88% men) were studied.Other inclusion criteria were left ventricular ejection fraction of Յ40 and sinus rhythm.Exclusion criteria were unstable angina, recent acute myocardial infarction, decompensated congestive heart failure, hemodynamically important valvular heart disease, severe chronic pulmonary illness, uncontrolled hypertension, renal insufficiency, or orthopedic or neurologic limitations.Followup was 95%.
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Romualdo Belardinelli (2000) conducted an RCT in chronic heart failure (n=99). Exercise training vs. Control was evaluated on All-cause mortality, cardiac events, and quality of life. Long-term exercise training for patients with chronic heart failure reduced mortality and cardiac events and improved quality of life.
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