Key result
Atropine yields similar heart rate responses in Down's syndrome patients versus controls.
Why the study?
A previous report suggested abnormally rapid heart rates and a potentially dangerous idiosyncratic response to atropine in patients with Down's syndrome.
Does atropine cause an abnormally rapid heart rate response in patients with Down's syndrome compared to controls?
Does atropine cause an abnormally rapid heart rate response in patients with Down's syndrome compared to controls?
Atropine does not cause an abnormally rapid heart rate response in patients with Down's syndrome compared to other patients with mental retardation, challenging previous reports of a dangerous idiosyncrasy.
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Similar atropine response in Down syndrome; challenges prior idiosyncrasy reports yet leaves open randomized confirmation.
Mir et al. (1971) studied Down's syndrome (n=41). Atropine vs. Control subjects with mental retardation not due to Down's syndrome was evaluated on Heart rate response. Atropine administration in doses of 30 to 60 μg/kg produced a similar heart rate response in patients with Down's syndrome compared to control subjects with mental retardation.
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