Key result
Initial two-drug fixed-dose combinations for hypertension provide greater cardiovascular mortality reduction compared to monotherapy but remain underutilized in clinical practice.
Why the study?
Does initial two-drug fixed-dose combination treatment reduce cardiovascular mortality compared to monotherapy in hypertension?
Does initial two-drug fixed-dose combination treatment reduce cardiovascular mortality compared to monotherapy in hypertension?
This editorial highlights that initial single-pill combinations for antihypertensive treatment offer greater cardiovascular mortality reduction compared to monotherapy, yet remain underutilized.
This editorial refers to 'Early cardiovascular protection by initial two-drug fixed-dose combination treatment vs. monotherapy in hypertension' † , by F. Rea et al., on page 3654.
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Ali et al. (2018) studied this question. Initial two-drug fixed-dose combinations for hypertension provide greater cardiovascular mortality reduction compared to monotherapy but remain underutilized in clinical practice.
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