Key result
Vasa vasorum hypoperfusion and plasmin/MMP activation drive AAA development, offering novel therapeutic targets.
Why the study?
The full mechanism of MMPs activation contributing to abdominal aortic aneurysm wall structural disruption remains unclear, motivating investigation into the PA/Plasmin system's role.
The PA/Plasmin system and its role in tissue fibrinolysis and MMP activation may serve as a novel therapeutic target for preventing the progression and rupture of abdominal aortic aneurysms.
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Hiroki Tanaka (2017) conducted a review in Abdominal aortic aneurysm. Coagulation-fibrinolysis system targeted therapy was evaluated. Hypoperfusion of the vasa vasorum and activation of the plasminogen activator/plasmin/MMPs system are key drivers of abdominal aortic aneurysm development, offering potential novel therapeutic targets.
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