Key result
Ringer's lactate reduces fluid retention index ~19% vs hydroxyethyl starch in the first hour of surgery.
Why the study?
Renal fluid conservation caused by dehydration can be quantified by urine analysis, but it is unclear whether fluid retention can be reversed by crystalloid or colloid fluids during surgery.
Does Ringer's lactate compared to hydroxyethyl starch improve fluid retention in patients undergoing major abdominal surgery?
Population
108 patients undergoing major abdominal surgery
Comparison
Flow-guided fluid volume optimisation with hydroxyethyl starch 130/0.4 vs Ringer's lactate
Design
Open-labeled clinical trial
Follow-up
Postoperative
Authors
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May favor Ringer's lactate over hydroxyethyl starch in abdominal surgery; leaves open effects on renal outcomes.
Does Ringer's lactate compared to hydroxyethyl starch improve fluid retention in patients undergoing major abdominal surgery?
p-value: p=<0.01
In patients undergoing major abdominal surgery, Ringer's lactate, but not hydroxyethyl starch, effectively decreases urinary markers of fluid retention, which is associated with postoperative serum creatinine increases.
Hahn et al. (2016) studied major abdominal surgery (n=108). Ringer's lactate vs. hydroxyethyl starch 130/0.4 was evaluated on fluid retention index (FRI) (p=<0.01). Ringer's lactate, but not hydroxyethyl starch, significantly decreased the fluid retention index from 3.6 to 2.9 during the first hour of surgery (P<0.01).
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